Searching Synergistic Dose Combinations for Anticancer Drugs

Monoclonal Antibody Combinations that Present Synergistic Neutralizing Activity: A Platform for Next-Generation Anti-Toxin Drugs

Monoclonal antibodies (MAbs) are among the fastest-growing therapeutics and are being developed for a broad range of indications, including the neutralization of toxins, bacteria and viruses. Nevertheless, MAbs potency is still relatively low when compared to conventional polyclonal Ab preparations. Moreover, the efficacy of an individual neutralizing MAb may significantly be hampered by the po...

Searching for Synergism Among Combinations of Drugs of Abuse and the Use of Isobolographic Analysis

It is well known that individuals who abuse drugs usually use more than one substance. Toxic consequences of single and multiple drug use are well documented in the Treatment Episodes Data Set (TEDS) that lists combinations that result in hospital admissions. Using this list as a guide, we focused our attention on combinations that result in the most hospital admissions and searched the PubMed ...

Fixed-dose combinations of drugs versus single-drug formulations for treating pulmonary tuberculosis

BACKGROUND People who are newly diagnosed with pulmonary tuberculosis (TB) typically receive a standard first-line treatment regimen that consists of two months of isoniazid, rifampicin, pyrazinamide, and ethambutol followed by four months of isoniazid and rifampicin. Fixed-dose combinations (FDCs) of these drugs are widely recommended. OBJECTIVES To compare the efficacy, safety, and acceptab...

Derivative spectrophotometric method for estimation of antiretroviral drugs in fixed dose combinations.

PURPOSE Lamivudine is cytosine and zidovudine is cytidine and is used as an antiretroviral agents. Both drugs are available in tablet dosage forms with a dose of 150 mg for LAM and 300 mg ZID respectively. METHOD The method employed is based on first order derivative spectroscopy. Wavelengths 279 nm and 300 nm were selected for the estimation of the Lamovudine and Zidovudine respectively by t...

Natural Based Anticancer Drugs and Their Worthiness